TTP 22( TTP 22 | TTP-22 | TTP22 )

Catalog No. M14092 CAS No. 329907-28-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TTP 22
Note

Research use only, not for human use.
Brief Description

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM.
Description

TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM; shows selectivity for CK2 over JNK3, ROCK1, and MET(IC50> 10 uM).
In Vitro

TTP 22 is a potent CK2 inhibitor, with an IC50 of 100 nM and a Ki of 40 nM. TTP 22 shows no effect on other kianses such as Jnk3, Rock1, Tie2, Ask1, Met and FGFR1 at 10 μM.
In Vivo

——
Synonyms

TTP 22 | TTP-22 | TTP22
Pathway

Metabolic Enzyme/Protease
Target

Casein Kinase
Recptor

CK2
Research Area

Cancer
Indication

——

CAS Number

329907-28-0
Formula Weight

330.42
Molecular Formula

C16H14N2O2S2
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL
SMILES

O=C(O)CCSC1=C(C(C2=CC=C(C)C=C2)=CS3)C3=NC=N1
Chemical Name

3-[[5-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]-propanoic acid

1.Golub AG, et al. Eur J Med Chem. 2011 Mar;46(3): 870-6.

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