7-Chlorokynurenic acid

Research use only, not for human use.

7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site.

7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.(In Vivo):In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.

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Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline

Neuroscience

GluR

CDK

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18000-24-3

223.61

C10H6ClNO3

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (74.55 mM)

O=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1

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(-20℃)

With Ice Pack

≥ 2 years