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Indotecan

CAS No. 915303-09-2

Indotecan( LMP-400 | NSC-724998 )

Catalog No. M24962 CAS No. 915303-09-2

Indotecan is an effective inhibitor of topoisomerase 1(Top1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Indotecan
  • Note
    Research use only, not for human use.
  • Brief Description
    Indotecan is an effective inhibitor of topoisomerase 1(Top1).
  • Description
    Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Female BALB/c mice (4-6 weeks) were infected with metacyclic parasites intravenously through the tail vein Dosage:2.5 mg/kg body weight per injection Administration:Intraperitoneally every 2 days for 15 days (total, eight doses)Result:A drastic reduction of the number of transforming amastigotes recovered from the target organs of drug-treated animals was observed.
  • Synonyms
    LMP-400 | NSC-724998
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    topoisomerase I
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    915303-09-2
  • Formula Weight
    478.49
  • Molecular Formula
    C26H26N2O7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : < 1 mg/mL (insoluble o)
  • SMILES
    O=C1N(CCCN2CCOCC2)C3=C(C(C4=C3C=C(OCO5)C5=C4)=O)C6=C1C=C(OC)C(OC)=C6
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.
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