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AMN082

CAS No. 83027-13-8

AMN082( —— )

Catalog No. M24820 CAS No. 83027-13-8

AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AMN082
  • Note
    Research use only, not for human use.
  • Brief Description
    AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
  • Description
    AMN082 is a metabotropic glutamate receptor 7 allosteric agonist.
  • In Vitro
    Preincubation of the synaptosomes with AMN082 (1 μM) for 10 min before 4-aminopyridine treatment efficiently inhibits the 4-aminopyridine-evoked release of glutamate, without altering the basal release of glutamate.
  • In Vivo
    AMN082 (6 mg/kg; p.o.) induces stress hormone increases in an mGluR7-dependent fashion in mGluR7+/+ mice (C57BL/6 genetic background).AMN082 (1.25-5.0 mg/kg, i.p.; 30 min before every Cocaine injection during repeated drug administration or before Cocaine challenge) dose-dependently attenuates the development, as well as the expression of Cocaine locomotor sensitization.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    GluR
  • Recptor
    mGluR7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    83027-13-8
  • Formula Weight
    392.54
  • Molecular Formula
    C28H28N2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 12.5 mg/mL (31.84 mM)
  • SMILES
    C(CNC(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Marszalek, M, Komsta, et al. AMN082, a metabotropic glutamate receptor 7 allosteric agonist, attenuates locomotor sensitization and cross-sensitization induced by cocaine and morphine in mice[J]. Progress in Neuro Psychopharmacology & Biological Psychiatry An International Research Review & News Journal, 2015.
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