Evans blue( —— )

Catalog No. M14013 CAS No. 314-13-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Evans blue
Note

Research use only, not for human use.
Brief Description

Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT).
Description

Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively).
In Vitro

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In Vivo

Animal Model:CD-1 mice bearing intracerebral hemorrhage (ICH)Dosage:2% solution; 4 mL/kg Administration:Jugular vein or intraperitoneal injection; once Result:Showed the amount of stain accumulated in the brains.
Synonyms

——
Pathway

Neuroscience
Target

GluR
Recptor

vesicular glutamate uptake
Research Area

Other Indications
Indication

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CAS Number

314-13-6
Formula Weight

960.78
Molecular Formula

C34H24N6Na4O14S4
Purity

>98% (HPLC)
Solubility

Water: 10 mM
SMILES

CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N/N=C\3/C(=O)C4=C(C(=CC(=C4N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C3)C)N/N=C\5/C(=O)C6=C(C(=CC(=C6N)S(=O)(=O)[O-])S(=O)(=O)[O-])C=C5.[Na+].[Na+].[Na+].[Na+]
Chemical Name

——

1.Shen Y, et al. Biomed Mater Eng. 2014;24(6):2831-8.

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