Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively.

Propyphenazone is a pyrazolone derivative with anti-inflammatory analgesic and antipyretic activity Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.

6-paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants and exhibits a variety of biological activities including anti-cancer anti-inflammatory and anti-oxidative activitiesneuroprotective Effects.