Cystamine dihydrochloride

Research use only, not for human use.

Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.

Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.

Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione. Western Blot Analysis Cell Line:Human neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3.Inhibited the H2O2-mediated activation of caspase-3.Inhibited caspase-3 activity in a tTG-independent manner.

Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice. Animal Model:R6/2 transgenic HD miceDosage:112, 225 mg/kg Administration:Intraperitoneal or oral, daily Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.

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Others

Other Targets

Others

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56-17-7

225.19

C4H14Cl2N2S2

>98% (HPLC)

DMSO:Soluble

C(CSSCCN)N.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years