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Cystamine dihydrochloride

CAS No. 56-17-7

Cystamine dihydrochloride( —— )

Catalog No. M24550 CAS No. 56-17-7

Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 39 In Stock
5MG 49 In Stock
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Biological Information

  • Product Name
    Cystamine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
  • Description
    Cystamine dihydrochloride is a radiation-protective agent. It also protects against carbon tetrachloride liver damage.
  • In Vitro
    Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM.Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner. Cystamine (250 μM; 10 h) robustly increases the levels of glutathione. Western Blot Analysis Cell Line:Human neuroblastoma SH-SY5Y cells Concentration:250, 500 μM Incubation Time:0-16 h Result:Inhibited the MG132-mediated activation of caspase-3.Inhibited the H2O2-mediated activation of caspase-3.Inhibited caspase-3 activity in a tTG-independent manner.
  • In Vivo
    Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice. Animal Model:R6/2 transgenic HD miceDosage:112, 225 mg/kg Administration:Intraperitoneal or oral, daily Result:Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    56-17-7
  • Formula Weight
    225.19
  • Molecular Formula
    C4H14Cl2N2S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    C(CSSCCN)N.Cl.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Roncoroni L, Elli L, Braidotti P, et al. Transglutaminase 2 Mediates the Cytotoxicity of Resveratrol in a Human Cholangiocarcinoma and Gallbladder Cancer Cell Lines. Nutr Cancer. 2018 May 14:1-9.
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