Karanjin

Research use only, not for human use.

Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity.

Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis.

Cell Cycle Analysis Cell Line:A549, HL-60 Concentration:4, 6, 8 μM for A549, 2, 4, 6 μM for HL-60 Incubation Time:72 h Result:Blocked the cell cycle markedly at G2/M phase of A549 (>60% for 8 μM) and HL-60 (>40% for 6 μM)

Animal Model:Streptozotocin-induced diabetic ratsDosage:50, 100 mg/kg Administration:Oral gavage (p.o.), wait for 6hResult:Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage.Animal Model:Adjuvant induced arthritis model (AIA) Wistar strain male albino rats Dosage:10, 20 mg/kg/d Administration:Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examinationResult:Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly.Animal Model:Diazepam-induced male swiss albino mice Dosage:25, 50 mg/kg/d Administration:Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d Result:Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.

——

Membrane Transporter/Ion Channel

AMPK

AMPK

——

——

521-88-0

292.29

C18H12O4

>98% (HPLC)

DMSO:10 mM

O=C1C(OC)=C(C2=CC=CC=C2)OC3=C1C=CC4=C3C=CO4

——

(-20℃)

With Ice Pack

≥ 2 years