Cart
sales@molnova.com
PF-06885249
CAS No. 1467059-70-6
PF-06885249( PF06885249 )
Catalog No. M12001 CAS No. 1467059-70-6
PF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 102 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 150 | In Stock |
|
| 25MG | 250 | In Stock |
|
| 50MG | 355 | In Stock |
|
| 100MG | 498 | In Stock |
|
| 200MG | 684 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePF-06885249
-
NoteResearch use only, not for human use.
-
Brief DescriptionPF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively.
-
DescriptionPF-06885249 (PF06885249) is a potent, direct AMPK activator with EC50 of 7.0 and 27 nM for α1β1γ1 and α2β1γ1, respectively; displays no activity for α1β2γ1, α2β2γ1 and α2β2γ3 complexes (EC50>40 uM).
-
In Vitro——
-
In Vivo——
-
SynonymsPF06885249
-
PathwayMembrane Transporter/Ion Channel
-
TargetAMPK
-
RecptorAMPK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1467059-70-6
-
Formula Weight345.783
-
Molecular FormulaC17H16ClN3O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (289.20 mM)
-
SMILESO=C(C1=CNC2=C1C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)O
-
Chemical Name6-chloro-5-(6-(dimethylamino)-2-methoxypyridin-3-yl)-1H-indole-3-carboxylic acid
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ryder T, et al. J Med Chem. 2018 Jul 23. doi: 10.1021/acs.jmedchem.8b00807.
molnova catalog
related products
-
ZLN-024 hydrochlorid...
A novel AMPK allosteric activator that has no effect on mitochondrial function or the ADP/ATP ratio; directly activate recombinant AMPK α1β1γ1 and its homologue α2β1γ1 with EC50 of 0.42 uM and 0.95 uM, respectively.
-
MT 63-78
MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM). MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways.
-
Brazilin
Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific signaling pathway.
