Cart
sales@molnova.com
sbp-7455
CAS No. 1884222-74-5
sbp-7455( —— )
Catalog No. M23859 CAS No. 1884222-74-5
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 109 | In Stock |
|
| 10MG | 182 | In Stock |
|
| 25MG | 328 | In Stock |
|
| 50MG | 535 | In Stock |
|
| 100MG | 671 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Namesbp-7455
-
NoteResearch use only, not for human use.
-
Brief DescriptionSBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
-
DescriptionSBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorULK1|ULK2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1884222-74-5
-
Formula Weight354.33
-
Molecular FormulaC16H17F3N4O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:120mg/mL (338.67 mM)
-
SMILESCOC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020;63(23):14609-14625. doi:10.1021/acs.jmedchem.0c00873
molnova catalog
related products
-
Ammonium Chloride
Ammonium chloride acts as a small molecule autophagy inhibitor.Ammonium chloride is a pH-regulating, heteropolar compound that can cause intracellular alkalosis and metabolic acidosis, thereby affecting enzyme activity and influencing processes in biological systems.
-
Biotin-aniline
Biotin-aniline is a probe that reacts strongly to RNA and DNA.Biotin-aniline is highly efficient and is used to capture subcellular transcriptomes in living cells with high spatial specificity.
-
PHY34
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers.
