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sbp-7455

CAS No. 1884222-74-5

sbp-7455( —— )

Catalog No. M23859 CAS No. 1884222-74-5

SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 192 In Stock
25MG 346 In Stock
50MG 552 In Stock
100MG 693 In Stock
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Biological Information

  • Product Name
    sbp-7455
  • Note
    Research use only, not for human use.
  • Brief Description
    SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
  • Description
    SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    ULK1|ULK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1884222-74-5
  • Formula Weight
    354.33
  • Molecular Formula
    C16H17F3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/mL (338.67 mM)
  • SMILES
    COC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020;63(23):14609-14625. doi:10.1021/acs.jmedchem.0c00873
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