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sbp-7455
CAS No. 1884222-74-5
sbp-7455( —— )
Catalog No. M23859 CAS No. 1884222-74-5
SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 115 | In Stock |
|
| 10MG | 192 | In Stock |
|
| 25MG | 346 | In Stock |
|
| 50MG | 552 | In Stock |
|
| 100MG | 693 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Namesbp-7455
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NoteResearch use only, not for human use.
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Brief DescriptionSBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
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DescriptionSBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorULK1|ULK2
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Research Area——
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Indication——
Chemical Information
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CAS Number1884222-74-5
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Formula Weight354.33
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Molecular FormulaC16H17F3N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:120mg/mL (338.67 mM)
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SMILESCOC1=C(OC)C=CC(NC2=NC(NC3CC3)=C(C(F)(F)F)C=N2)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ren H, Bakas NA, Vamos M, et al. Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2020;63(23):14609-14625. doi:10.1021/acs.jmedchem.0c00873
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