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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - API-1

API-1

CAS No. 36707-00-3

API-1( NSC177223 )

Catalog No. M24326 CAS No. 36707-00-3

API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    API-1
  • Note
    Research use only, not for human use.
  • Brief Description
    API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
  • Description
    API-1 is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC177223
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    Akt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    36707-00-3
  • Formula Weight
    337.29
  • Molecular Formula
    C13H15N5O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C1=C(C(=O)C2=C(N=CN=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N)C(=O)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ren H , Koo J , Guan B , et al. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis[J]. Molecular Cancer, 2013, 12(1):146-146.
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