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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Akt - NSC 86429

NSC 86429

CAS No. 5812-07-7

NSC 86429( SU-4312 | SU 4312 | SU4312. DMBI | NSC 86429 )

Catalog No. M17109 CAS No. 5812-07-7

SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 86429
  • Note
    Research use only, not for human use.
  • Brief Description
    SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively).
  • Description
    SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
  • In Vitro
    Receptor tyrosine kinases (RTKs) have been shown to be important mediators of cellular signal transduction in cells. Many RTKs have been shown to be oncogene products implicating their role in the transformation process associated with human cancers.
  • In Vivo
    ——
  • Synonyms
    SU-4312 | SU 4312 | SU4312. DMBI | NSC 86429
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Akt
  • Recptor
    PDGFR| VEGFR
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    5812-07-7
  • Formula Weight
    264.33
  • Molecular Formula
    C17H16N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (189.16 mM)
  • SMILES
    CN(C)C1=CC=C(C=C1)/C=C\2/C3=CC=CC=C3NC2=O
  • Chemical Name
    3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li Y, et al. Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation. Endocrinology. 2015 Nov;156(11):4257-68.
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