Cart
sales@molnova.com
FAUC-213
CAS No. 337972-47-1
FAUC-213( FAUC 213 | FAUC213 )
Catalog No. M24286 CAS No. 337972-47-1
FAUC-213 is a selective full antagonist of the dopamine D4 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 31 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 85 | In Stock |
|
| 25MG | 170 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameFAUC-213
-
NoteResearch use only, not for human use.
-
Brief DescriptionFAUC-213 is a selective full antagonist of the dopamine D4 receptor.
-
DescriptionFAUC-213 is a selective full antagonist of the dopamine D4 receptor.
-
In VitroFAUC 213 inhibits p5-HT1 (Ki=1.2 μM)，p5-HT2 (Ki=0.52 μM)，pα1 (Ki=0.27 μM).
-
In VivoFAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg. Animal Model:Male adult Wistar rats weighing 300-350 g Dosage:7.5, 15, 30 mg/kg Administration:Orally; single dose Result:Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
-
SynonymsFAUC 213 | FAUC213
-
PathwayGPCR/G Protein
-
TargetDopamine Receptor
-
RecptorD4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number337972-47-1
-
Formula Weight326.82
-
Molecular FormulaC18H19ClN4
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESC1CN(CCN1CC2=NN3C=CC=CC3=C2)C4=CC=C(C=C4)Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.St??el A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P. Development of molecular tools based on the dopamine D(3) receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorg Med Chem. 2017 Jul 1;25(13):3491-3499. doi: 10.1016/j.bmc.2017.04.036. Epub 2017 Apr 29. PubMed PMID: 28495386; PubMed Central PMCID: PMC5512454.
molnova catalog
related products
-
A-437203
A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ? old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM.
-
Tipepidine hydrochlo...
Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
-
Acetophenazine dimal...
Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor.
