Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Dopamine Receptor - SB-277011

SB-277011

CAS No. 215803-78-4

SB-277011( SB-277011-A | SB-277011A | SB277011 | SB 277011 )

Catalog No. M13441 CAS No. 215803-78-4

A potent and selective dopamine D3 receptor antagonist with pKi of 8.0.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 80 Get Quote
10MG 128 Get Quote
25MG 240 Get Quote
50MG 401 Get Quote
100MG 590 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SB-277011
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
  • Description
    A potent and selective dopamine D3 receptor antagonist with pKi of 8.0; displays >100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors; exhibits high oral bioavailability and brain penetration in rats.Schizophrenia Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB-277011-A | SB-277011A | SB277011 | SB 277011
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    215803-78-4
  • Formula Weight
    438.564
  • Molecular Formula
    C28H30N4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
  • Chemical Name
    4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stemp G, et al. J Med Chem. 2000 May 4;43(9):1878-85. 2. Reavill C, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65. 3. Ashby CR Jr, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1166-74.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Fosopamine(HCl)

    Fosopamine(HCl) is a DRDs agonist that can be used to study hypertension.

  • Talipexole dihydroch...

    Talipexole dihydrochloride is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, respectively. It displays antiParkinsonian activity.

  • A-437203

    A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ? old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM.

Sign In Join Free