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SB-277011
CAS No. 215803-78-4
SB-277011( SB-277011-A | SB-277011A | SB277011 | SB 277011 )
Catalog No. M13441 CAS No. 215803-78-4
A potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 5MG | 50 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 152 | In Stock |
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| 50MG | 248 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB-277011
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective dopamine D3 receptor antagonist with pKi of 8.0.
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DescriptionA potent and selective dopamine D3 receptor antagonist with pKi of 8.0; displays >100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors; exhibits high oral bioavailability and brain penetration in rats.Schizophrenia Discontinued.
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In Vitro——
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In Vivo——
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SynonymsSB-277011-A | SB-277011A | SB277011 | SB 277011
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine Receptor
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number215803-78-4
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Formula Weight438.564
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Molecular FormulaC28H30N4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
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Chemical Name4-Quinolinecarboxamide, N-[trans-4-[2-(6-cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stemp G, et al. J Med Chem. 2000 May 4;43(9):1878-85.
2. Reavill C, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65.
3. Ashby CR Jr, et al. J Pharmacol Exp Ther. 2000 Sep;294(3):1166-74.
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