Deoxyelephantopin

Research use only, not for human use.

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling

Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling.

Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC50s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively.Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells.

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Apoptosis

NF-κB

NF-κB

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29307-03-7

344.37

C19H20O6

>98% (HPLC)

DMSO:10 mM

O=C(O[C@H]([C@]([H])([C@]([H])(OC1=O)C=C(C)C2)C1=C)CC3=C[C@@]2(OC3=O)[H])C(C)=C

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(-20℃)

With Ice Pack

≥ 2 years