CHPG sodium salt

Research use only, not for human use.

CHPG sodium salt is a selective agonist of mGluR5 that activates ERK and Akt signaling pathways and is utilized in studies on traumatic brain injury.

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..

Cell Viability Assay Cell Line:BV2 microglial cells Concentration:10, 50, 100 and 500?μM Incubation Time:24?hours Result:Increased the cell viability. Apoptosis Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Protected BV2 cells against SO2-induced apoptosis.Western Blot Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Increased the expression of TSG-6 in both mRNA and protein levels.

Animal Model:Adult Sprague-Dawley male rats weighing 280-320 g Dosage:250 nM Administration:Injection; for 7 days Result:Reduced significantly cerebral lesion volume.

——

Apoptosis

NF-κB

NF-κB | GluR

——

——

1303993-73-8

223.59

C8H7ClNNaO3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (447.25 mM; Ultrasonic ) H2O : 6.67 mg/mL (29.83 mM; Ultrasonic (<80°C)

C1=CC(=C(C=C1O)C(C(=O)[O-])N)Cl.[Na+]

——

(-20℃)

With Ice Pack

≥ 2 years