Saikosaponin A( Saikosaponin A )

Catalog No. M13225 CAS No. 20736-09-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Saikosaponin A
Note

Research use only, not for human use.
Brief Description

Extracted from Bupleurum,scorzonerifolium;Suitability:Water,dilute alcohol,especially the hot water,hot alcohol,butanol and pentanol;Store the product in sealed,cool and dry condition
Description

Extracted from Bupleurum,scorzonerifolium;Suitability:Water,dilute alcohol,especially the hot water,hot alcohol,butanol and pentanol;Store the product in sealed,cool and dry condition.
In Vitro

Western Blot Analysis Cell Line:Human osteoarthritis chondrocytes Concentration:5, 10, 15 μM Incubation Time:24 h Result:Inhibited the levels of phosphorylation of NF-κB p65 and IκBα induced byIL-1β.Up-regulated the expression of LXRα in a dose-dependent manner.
In Vivo

Animal Model:5-FU (HY-90006)-induced mucositis in BALB/c mice modle Dosage:1, 5, 10?mg/kg/day, 7 d Administration:injected intraperitoneally (i.p)Result:Reduced villus blunting, crypt cells apoptosis, and inflammatory cell infiltration.Decreased concentration of GSH, GST, Catalase, and SOD in intestinal tissue.
Synonyms

Saikosaponin A
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB
Research Area

Other Indications
Indication

——

CAS Number

20736-09-8
Formula Weight

780.99
Molecular Formula

C42H68O13
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O[C@H]([C@H]([C@@H]([C@@H](C)O1)O)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@H]1OC3CC[C@]4(C)[C@@]5([H])C=C[C@]67[C@]8([H])CC(C)(C)CC[C@@](CO7)8[C@H](O)C[C@](C)6[C@@](C)5CC[C@]([H])4[C@]3(C)CO
Chemical Name

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5R,6R)-3,5-dihydroxy-2-(((4R,4aR,6aR,6bS,8R,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-2,3,4,4a,5,6,6a,6b,7,8,10,11,12,12a,14a,14b-hexadecahydro-1H,9H-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

1.Zhao H, et al. Exp Ther Med. 2015 Aug;10(2):823-827.

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