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GSK620
CAS No. 2088410-46-0
GSK620( —— )
Catalog No. M23936 CAS No. 2088410-46-0
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 42 | In Stock |
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| 10MG | 67 | In Stock |
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| 25MG | 139 | In Stock |
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| 50MG | 219 | In Stock |
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| 100MG | 324 | In Stock |
|
| 200MG | 483 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameGSK620
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NoteResearch use only, not for human use.
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Brief DescriptionGSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.
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DescriptionGSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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Recptorpan-BD2
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Research Area——
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Indication——
Chemical Information
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CAS Number2088410-46-0
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Formula Weight325.4
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Molecular FormulaC18H19N3O3
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL (192.09 mM; Need ultrasonic)
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SMILESCNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.
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