3,4,5-Trimethoxy-trans-cinnamic acid

Research use only, not for human use.

3,4,5-Trimethoxy-trans-cinnamic acid is a natural product from the roots and rhizomes of Notopterygium incisum.

3,4,5-Trimethoxy-trans-cinnamic acid is a natural product from the roots and rhizomes of Notopterygium incisum.

(E)-3,4,5-Trimethoxycinnamic acid (10 μg/mL, 1 h) increases the expressions of GAD65 and γ-subunit of GABAA receptors in the cerebellar granule cells.(E)-3,4,5-Trimethoxycinnamic acid (0-10 μg/mL, 1 h) shows a significant increase in Cl- influx. Western Blot Analysis Cell Line:Primary cultured cerebellar granule cells Concentration:10 μg/mL Incubation Time:1 h Result:Increased expression of GAD65 (glutamic acid decarboxylase) and γ-subunit of GABAA receptors, but did not influence the amounts of a-, b-subunits in the GABAA receptors.Cell Viability Assay Cell Line:Primary cultured cerebellar granule cellsConcentration:1, 3, 5, 10 μg/mL Incubation Time:1 h Result:Produced a significant increase in Cl- influx.

(E)-3,4,5-Trimethoxycinnamic acid (0-20 mg/kg, IP, once) shows anti-seizure effects.(E)-3,4,5-Trimethoxycinnamic acid (0-10 mg/kg, Orally, once) enhances hypnotic effects in pentobarbital-treated mice. Animal Model:Ault male KunMing-strain mice (18-20 g, maximal electroshock (MES) and pentylenetetrazol (PTZ) models)Dosage:5, 10 and 20 mg/kg; 10 mL/kg Administration:IP, once Result:Significantly decreased the incidence of MES-induced THE (tonic hindlimb extension) to 50% and 20% of the value of the vehicle controls at 10 and 20 mg/kg. Decreased the incidence of MES-induced THE to only 80% at 5 mg/kg. Significantly delayed the onset of myoclonic jerks (MJ), and decreased the seizure severity and mortality compared with the vehicle-treated animals in PTZ seizure model. The incidence of generalized clonic convulsions (stage 4) disappeared at doses of both 10 and 20 mg/kg.Animal Model:ICR male mice (25-28 g, 10-12 in each group)Dosage:2, 5 and 10 mg/kg Administration:Orally (p.o.), once, 15 min and 1 h prior to pentobarbital injection Result:Significantly decreased locomotor activity at 10 mg/kg. Increased NREM and total sleep, but decreased wakefulness.

O-Methylsinapic acid | 3,4,5-Trimethoxyphenylacrylic acid

Others

Other Targets

Others

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20329-98-0

238.24

C12H14O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (419.74 mM)

COc1cc(/C=C/C(O)=O)cc(OC)c1OC

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(-20℃)

With Ice Pack

≥ 2 years