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Tolebrutinib
CAS No. 1971920-73-6
Tolebrutinib( SAR442168 | PRN2246 )
Catalog No. M23893 CAS No. 1971920-73-6
Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 73 | In Stock |
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| 2MG | 34 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 107 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 272 | In Stock |
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| 100MG | 449 | In Stock |
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| 200MG | 644 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTolebrutinib
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NoteResearch use only, not for human use.
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Brief DescriptionTolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively).
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DescriptionTolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS).
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In Vitro——
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In Vivo——
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SynonymsSAR442168 | PRN2246
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research Area——
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Indication——
Chemical Information
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CAS Number1971920-73-6
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Formula Weight455.51
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Molecular FormulaC26H25N5O3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (219.53 mM; Need ultrasonic)
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SMILESC=CC(N(CCC1)C[C@@H]1N(c(ccnc1N)c1N1c(cc2)ccc2Oc2ccccc2)C1=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Francesco MR, et, al. PRN2246, a potent and selective blood brain barrier penetrating BTK inhibitor, exhibits efficacy in central nervous system immunity. Multiple Sclerosis Journal. 2017;Poster Session 2:P989.
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