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MDVN-1003
CAS No. 2058116-54-2
MDVN-1003( MDVN1003 | MDVN 1003 )
Catalog No. M13199 CAS No. 2058116-54-2
A first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameMDVN-1003
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NoteResearch use only, not for human use.
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Brief DescriptionA first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively.
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DescriptionA first-in-class, selective, orally bioavailable, dual inhibitor of BTK and PI3Kδ kinases with IC50 of 32.3 nM and 16.9 nM, respectively; inhibits B cell activation upon BCR cross-linking ex vivo and in vivo, induces apoptosis and decreases viability of DOHH-2 cells; shows significant anti-tumor effects in an NHL xenograft model in mice.
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In Vitro——
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In Vivo——
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SynonymsMDVN1003 | MDVN 1003
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PathwayTyrosine Kinase
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TargetBTK
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RecptorBTK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number2058116-54-2
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Formula Weight417.45
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Molecular FormulaC22H20FN7O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1COC2=C(N1)C=C(C=C2F)C3=NN(C4=NC=NC(=C34)N)C5CC6=C(C5)C=C(C=C6)N
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Chemical Name1-(5-amino-2,3-dihydro-1H-inden-2-yl)-3-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Alfaro J, et al. J Pharmacol Exp Ther. 2017 May;361(2):312-321.
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