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U 73343
CAS No. 142878-12-4
U 73343( —— )
Catalog No. M23589 CAS No. 142878-12-4
U 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 60 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 92 | In Stock |
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| 25MG | 187 | In Stock |
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| 50MG | 309 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameU 73343
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NoteResearch use only, not for human use.
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Brief DescriptionU 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant.
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DescriptionU 73343 is an inactive analog of U 73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC.
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In VitroU73343, which potently inhibits acid secretion, shows no inhibitory effect on either K+-pNPPase or H+,K+-ATPase activity. U73343 dose-dependently inhibits, histamine (Hist)-, carbachol (CCh)-, and dbcAMPstimulated aminopyrine accumulation in gastric glands.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPLC
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Research Area——
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Indication——
Chemical Information
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CAS Number142878-12-4
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Formula Weight466.66
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Molecular FormulaC29H42N2O3
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Purity>98% (HPLC)
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SolubilityDMSO:5 mg/mL (10.71 mM; Need ultrasonic)
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SMILESO=C(CC1)N(CCCCCCN[C@H]2CC[C@@]3([H])[C@]4([H])CCC5=CC(OC)=CC=C5[C@@]4([H])CC[C@]23C)C1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.
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