Cart
sales@molnova.com
Lp-PLA2-IN-3
CAS No. 2196245-16-4
Lp-PLA2-IN-3( —— )
Catalog No. M32996 CAS No. 2196245-16-4
Lp-PLA2-IN-3 is a potent, orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, effectively inhibiting recombinant human [Lp-PLA2] with an IC50 value of 14 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 233 | In Stock |
|
| 2MG | 135 | In Stock |
|
| 5MG | 227 | In Stock |
|
| 10MG | 359 | In Stock |
|
| 25MG | 596 | In Stock |
|
| 50MG | 824 | In Stock |
|
| 100MG | 1097 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2213 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLp-PLA2-IN-3
-
NoteResearch use only, not for human use.
-
Brief DescriptionLp-PLA2-IN-3 is a potent, orally bioactive lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, effectively inhibiting recombinant human [Lp-PLA2] with an IC50 value of 14 nM.
-
DescriptionLp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2).
-
In Vitro——
-
In VivoLp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively.Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively.Animal Model:Male Sprague?Dawley (SD) rats (180-220 g)Dosage:3 mg/kg Administration:p.o. (Pharmacokinetic Analysis)Result:The Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 6.2 μg h/mL, 7.7 hours and 35.5%, respectively.
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetPhospholipase
-
RecptorPhospholipase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2196245-16-4
-
Formula Weight467.85
-
Molecular FormulaC20H13ClF3N3O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : ≥ 250 mg/mL (534.36 mM )
-
SMILESNc1ccc(cc1)S(=O)(=O)Nc1ccc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(c1)C#N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Liu Q, et al. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2. J Med Chem. 2017 Dec 28;60(24):10231-10244.?
molnova catalog
related products
-
SB-435495
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
-
IACS-13909
IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.
-
Fuzapladib
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule.
