SPK-601( LMV-601 | SPK-0601 )

Catalog No. M10375 CAS No. 1096687-52-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SPK-601
Note

Research use only, not for human use.
Brief Description

A potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; shows antiviral activity against herpes simplex virus (HSV).
Description

A potent phosphatidylcholine-specific phospholipase C (PC-PLC) inhibitor; shows antiviral activity against herpes simplex virus (HSV); a novel antimicrobial agent.HSV Infection Phase 1 Clinical.
In Vitro

SPK-601 (72 hours; HPV-31 cells) displays a dose dependent inhibitory effect on cell growth (IC50 of 16 μg/mL), and inhibits HPV-31 specific RNA expression and DNA replication. Cell Viability Assay Cell Line:9E human papilloma virus (HPV)-31 infected cervical epithelial cells Concentration:Incubation Time:72 hours Result:A dose dependent inhibitory effect on cell growth.
In Vivo

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Synonyms

LMV-601 | SPK-0601
Pathway

Metabolic Enzyme/Protease
Target

Phospholipase
Recptor

Phospholipase
Research Area

Infection
Indication

HSV Infection

CAS Number

1096687-52-3
Formula Weight

266.4645
Molecular Formula

C11H15KOS2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

[S-]C(O[C@@H]1[C@@](C2)([H])[C@]3([H])CCCC3[C@@]2([H])C1)=S.[K+]
Chemical Name

Carbonodithioic acid, O-[(3aR,4R,5S,7R,7aR)-octahydro-4,7-methano-1H-inden-5-yl] ester, potassium salt (1:1), rel-(-)-

1. Walker K. IDrugs. 2010 Nov;13(11):743-5.

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