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VU590
CAS No. 313505-85-0
VU590( —— )
Catalog No. M33947 CAS No. 313505-85-0
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1) that also inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 36 | In Stock |
|
| 5MG | 57 | In Stock |
|
| 10MG | 93 | In Stock |
|
| 25MG | 155 | In Stock |
|
| 50MG | 230 | In Stock |
|
| 100MG | 346 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU590
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NoteResearch use only, not for human use.
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Brief DescriptionVU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1) that also inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.
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DescriptionVU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetPotassium Channel
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RecptorPotassium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number313505-85-0
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Formula Weight488.53
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Molecular FormulaC24H32N4O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (102.35 mM; Ultrasonic (<60°C)
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SMILESCl.Cl.[O-][N+](=O)c1ccc(CN2CCOCCOCCN(Cc3ccc(cc3)[N+]([O-])=O)CCOCC2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.?
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