JNJ 303( —— )

Catalog No. M20998 CAS No. 878489-28-2

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	88	In Stock
2MG	56	In Stock
5MG	86	In Stock
10MG	143	In Stock
25MG	326	In Stock
50MG	462	In Stock
100MG	690	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

JNJ 303
Note

Research use only, not for human use.
Brief Description

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
Description

JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
In Vitro

JNJ 303 can block IKs with an IC50 value of 64 nM. JNJ 303 (3.3 μM) does not have any effects on other cardiac channels.JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
In Vivo

JNJ 303 recapitulates the Exn4-induced decrease in fasting blood glucose level in mice.
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Potassium Channel
Recptor

IKs
Research Area

——
Indication

——

Chemical Information

CAS Number

878489-28-2
Formula Weight

440.98
Molecular Formula

C21H29ClN2O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (141.73 mM)
SMILES

CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1C2CC3CC1CC(NS(C)(=O)=O)(C3)C2
Chemical Name

2-(4-Chloro-phenoxy)-N-(5-methanesulfonylamino-adamantan-2-yl)-2-methyl-propionamide

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kang C Badiceanu A Brennan J A et al. β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle[J]. Scientific Reports 2017 7(1):15922.

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