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Cl-amidine hydrochloride

CAS No. 1373232-26-8

Cl-amidine hydrochloride( —— )

Catalog No. M23526 CAS No. 1373232-26-8

Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
5MG 85 In Stock
10MG 140 In Stock
25MG 275 In Stock
50MG 436 In Stock
100MG 631 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Cl-amidine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4).
  • Description
    Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro causing cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation. It improves survival in a murine sepsis model.
  • In Vitro
    Apoptosis Analysis.Cell Line:TK6 lymphoblastoid cells and HT29 colon cancer cells. Concentration:0, 5, 10, 15, 20, 25, 50 μg/mL.Incubation Time:24 h.Result:Induced apoptosis dose-dependently.
  • In Vivo
    Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis).Dosage:75 mg/kg.Administration:IP once daily.Result:Suppressed PAD activity, protein citrullination, and PAD levels in the colon in vivo.Animal Model:C57BL/6 mice (8-12 wk old, DSS mouse model of colitis). Dosage:5, 25, 75 mg/kg.Administration:Oral gavage once daily.Result:Led to significant reductions in the histology scores.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis|MicroRNA|PAD4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1373232-26-8
  • Formula Weight
    347.24
  • Molecular Formula
    C14H20Cl2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:50 mg/mL (143.99 mM; Need ultrasonic);DMSO:19.23 mg/mL (55.38 mM; Need ultrasonic)
  • SMILES
    O=C(N[C@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Yuan Luo, et al. Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization. Biochemistry. 2006 Oct 3; 45(39): 11727–11736.
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