NGP555

Research use only, not for human use.

NGP555 is a modulator of γ-secretase.

NGP555 is a modulator of γ-secretase.

NGP555 potently lowers Aβ42 in cell cultures (9 nM) while increasing shorter forms of Aβ.

NGP555 significantly lowers Aβ42 in the cerebrospinal fluid (CSF) at time points from 8 to10 hours post dose, panel B shows that reduction of Aβ cerebrospinal fluid (CSF) levels is significant at 3.75 mg/kg of NGP555 and above, and panel C shows an increase in Aβ38 levels at 15 mg/kg of NGP555 and above. When combining the reduction of Aβ42 with an increase in Aβ38, NGP555 is effective at raising CSF Aβ38/42 ratio at 1.87 mg/kg and above (panel D). NGP555-treated Tg mice show a significant protection from decline in performance with >65% less decline (P<0.005) when comparing the differential of Tg to non-Tg vehicle-treated mice. NGP555 also shows good oral bioavailability and is brain-penetrant with a brain:plasma ratio of ~0.93 in mice.

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Neuroscience

Gamma-secretase

γ secretase

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1304630-27-0

406.52

C23H23FN4S

>98% (HPLC)

DMSO:25 mg/mL (61.50 mM; Need ultrasonic)

CC1=CN(C2=CC=C(C3=CSC(NC4=CC(CC)=C(C)C=C4C)=N3)C=C2F)C=N1

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(-20℃)

With Ice Pack

≥ 2 years