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EST64454
CAS No. 1950569-11-5
EST64454( —— )
Catalog No. M22978 CAS No. 1950569-11-5
EST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 174 | In Stock |
|
| 5MG | 255 | In Stock |
|
| 10MG | 407 | In Stock |
|
| 25MG | 671 | In Stock |
|
| 50MG | 945 | In Stock |
|
| 100MG | 1251 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEST64454
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NoteResearch use only, not for human use.
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Brief DescriptionEST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
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DescriptionEST64454 is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.
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In Vitro——
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In VivoEST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively.EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively. Animal Model:Male Wistar rats (250-300 g) Dosage:10 mg/kg Administration:P.o. (Pharmacokinetic Analysis) Result:The Cmax, t1/2, AUC0-∞, Vss and F% were 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively.
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Synonyms——
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PathwayAutophagy
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TargetSigma receptor
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Recptorσ1
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Research Area——
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Indication——
Chemical Information
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CAS Number1950569-11-5
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Formula Weight400.85
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Molecular FormulaC18H23ClF2N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : ≥ 100 mg/mL (249.47 mM))
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SMILESCC(N1CCN(CCOCC2=NN(C3=CC=C(F)C(F)=C3)C=C2)CC1)=O.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.José Luis Díaz, Mónica García, Torrens A , et al. EST64454: a Highly Soluble σ 1 Receptor Antagonist Clinical Candidate for Pain Management[J]. Journal of Medicinal Chemistry, 2020, 63(23):14979-14988.
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