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Ipamorelin 2acetate(170851-70-4(free base))

CAS No. ——

Ipamorelin 2acetate(170851-70-4(free base))( NNC-26-0161 )

Catalog No. M22786 CAS No. ——

Ipamorelin 2acetate is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Ipamorelin 2acetate(170851-70-4(free base))
  • Note
    Research use only, not for human use.
  • Brief Description
    Ipamorelin 2acetate is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%).
  • Description
    Ipamorelin 2acetate is a growth-hormone-releasing peptide, induces longitudinal bone growth in rats.In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l and Emax = 85+/-5% vs 2.2+/-0.3nmol/l and 100%). A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin, like GHRP-6, stimulates GH release via a GHRP-like receptor[1]In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml). In conscious swine, ipamorelin released GH with an ED50 = 2.3+/-0.03 nmol/kg and an Emax = 65+/-0.2 ng GH/ml plasma. Again, this was very similar to GHRP-6 (ED50 = 3.9+/-1.4 nmol/kg and Emax = 74+/-7ng GH/ml plasma).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NNC-26-0161
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Digestive system
  • Indication
    Ileus

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    711.85
  • Molecular Formula
    C38H49N9O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(C)C(O)=O.CC(C)(C)C(O)=O.CC(C)(N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Raun K , Hansen B , Johansen N , et al. Ipamorelin, the first selective growth hormone secretagogue[J]. European Journal of Endocrinology, 1998, 139(5):552-561.
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