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Oxelumab

CAS No. 1186098-83-8

Oxelumab( —— )

Catalog No. M36764 CAS No. 1186098-83-8

Oxelumab (R 4930) is a human monoclonal antibody targeting OX40L, and could be used to study asthma.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Oxelumab
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxelumab (R 4930) is a human monoclonal antibody targeting OX40L, and could be used to study asthma.
  • Description
    Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.
  • In Vitro
    Cell Proliferation Assay Cell Line:Natural Killer (NK) cell lines Concentration:10 μg/mL Incubation Time:3 days Result:Inhibited cell proliferation of NK cells.
  • In Vivo
    Animal Model:NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI) Dosage:5 and 30 mg/kg Administration:Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13 Result:Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Interleukin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1186098-83-8
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Youngblood BA, et al. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019;180(2):91-102.?
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