Epimagnolin B( —— )

Catalog No. M22666 CAS No. 1134188-26-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Epimagnolin B
Note

Research use only, not for human use.
Brief Description

Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB.
Description

Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB. It also exhibits antiallergic effects without affecting the viability of bone marrow-derived mast cells.The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as Epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia.
In Vitro

Epimagnolin B exhibits antiallergic effects without affecting the viability of BMMCs.
In Vivo

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Synonyms

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Pathway

Immunology/Inflammation
Target

NOS
Recptor

NO Synthase|PGE|p65
Research Area

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Indication

——

CAS Number

1134188-26-3
Formula Weight

416.46
Molecular Formula

C23H28O7
Purity

>98% (HPLC)
Solubility

——
SMILES

[H][C@@]12CO[C@H](c3cc(OC)c(OC)c(OC)c3)[C@]1([H])CO[C@H]2c1cc(OC)cc(OC)c1
Chemical Name

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1. In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii.Bioorg Med Chem Lett. 2009 Feb 1;19(3):937-40.

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