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L-NIL
CAS No. 53774-63-3
L-NIL( —— )
Catalog No. M32991 CAS No. 53774-63-3
L-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3β in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 28 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameL-NIL
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NoteResearch use only, not for human use.
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Brief DescriptionL-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3β in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung.
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DescriptionL-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
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In Vitro——
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In VivoAnimal Model:Adult male Balb/c (20-25 g).Dosage:10 and 30?mg/kg.Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction. Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetNOS
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RecptorNOS
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Research Area——
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Indication——
Chemical Information
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CAS Number53774-63-3
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Formula Weight187.24
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Molecular FormulaC8H17N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 50 mg/mL (267.04 mM; Ultrasonic) DMSO : 1 mg/mL (5.34 mM; Ultrasonic )
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SMILESCC(=N)NCCCC[C@H](N)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634.?
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