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L-NIL

CAS No. 53774-63-3

L-NIL( —— )

Catalog No. M32991 CAS No. 53774-63-3

L-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3β in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-NIL
  • Note
    Research use only, not for human use.
  • Brief Description
    L-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3β in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung.
  • Description
    L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male Balb/c (20-25 g).Dosage:10 and 30?mg/kg.Administration:Intraperitoneally at the end of CLP and at 6?h after sepsis induction. Result:Led to a negligible increase in plasma NGAL compared to sham mice.Led to a significant decrease in both TLR4 and IL1β protein contents and clusterin transcript.Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    NOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    53774-63-3
  • Formula Weight
    187.24
  • Molecular Formula
    C8H17N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (267.04 mM; Ultrasonic) DMSO : 1 mg/mL (5.34 mM; Ultrasonic )
  • SMILES
    CC(=N)NCCCC[C@H](N)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634.?
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