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LDN-27219
CAS No. 312946-37-5
LDN-27219( —— )
Catalog No. M22644 CAS No. 312946-37-5
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 62 | In Stock |
|
| 5MG | 58 | In Stock |
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| 10MG | 88 | In Stock |
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| 25MG | 155 | In Stock |
|
| 50MG | 229 | In Stock |
|
| 100MG | 344 | In Stock |
|
| 200MG | 505 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLDN-27219
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NoteResearch use only, not for human use.
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Brief DescriptionLDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
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DescriptionLDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
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In VitroLDN-27219 (30 μM; 12 min) promotes the closed conformation of TGase 2 to activates calcium-activated potassium channels in smooth muscle cells.LDN-27219 (30 μM; 20-25 min) increases the response to acetylcholine in phenylephrine-contracted human subcutaneous arteries.
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In VivoLDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats. Animal Model:12 to 14-week-old male Wistar rats Dosage:0.1, 1 and 2 mg/kg Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once Result:Dose-dependently decreased mean arterial pressure of mice.Animal Model:12 to 14- and 35 to 40-week-old male Wistar rats Dosage:0.1, 1 and 2 mg/kg Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once Result:Decreased mean arterial pressure in old group more significant than young group.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorhTGase
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Research Area——
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Indication——
Chemical Information
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CAS Number312946-37-5
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Formula Weight408.5
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Molecular FormulaC20H16N4O2S2
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Purity>98% (HPLC)
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SolubilityDMSO:122 mg/mL (298.65 mM)
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SMILESNNC(=O)CSc1nc2scc(-c3ccccc3)c2c(=O)n1-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Case A, et al. Kinetic analysis of the interaction of tissue transglutaminase with a nonpeptidic slow-binding inhibitor. Biochemistry. 2007 Jan 30;46(4):1106-15.
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