Mizoribine

Research use only, not for human use.

An immunosuppressive agent that inhibits the proliferation of lymphocytes selectively, via inhibition of IMPDH.Rheumatoid ArthritisApproved

An immunosuppressive agent that inhibits the proliferation of lymphocytes selectively, via inhibition of IMPDH.Rheumatoid Arthritis Approved(In Vitro):Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects.Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome .(In Vivo):Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg.

Mizoribine, isolated from culture medium of the mold Eupenicillium brefeldianum M-2166, acts as an immunosuppressant which exerts its effects without severe side effects.Mizoribine is an inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitorused for renal transplantation, autoimmune diseases and steroid-resistant nephrotic syndrome .

Mizoribine suppresses collagen-induced arthritis. Mizoribine (10, 20 and 50 mg/kg; Administered orally 5 days a week for 12 weeks) reduces the arthritis score in a dose-dependent fashion, showing significant suppression, even at a dose of 10 mg/kg. Animal Model:Male DBA/1 J mice with collagen-induced arthritisDosage:10, 20 and 50 mg/kg Administration:Administered orally 5 days a week for 12 weeks Result:Showed dose-dependency of the suppressive effect.

NSC-289637 | HE-69

Others

Other Targets

monophosphatesynthetase

Inflammation/Immunology

Rheumatoid Arthritis

50924-49-7

259.216

C9H13N3O6

>98% (HPLC)

DMSO: ≥ 35 mg/mL

O=C(C1=C(O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=N1)N

1H-Imidazole-4-carboxamide, 5-hydroxy-1-β-D-ribofuranosyl-

(-20℃)

With Ice Pack

≥ 2 years