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AZD4747
CAS No. 2489226-14-2
AZD4747( —— )
Catalog No. M37231 CAS No. 2489226-14-2
AZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 548 | In Stock |
|
| 5MG | 566 | In Stock |
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| 10MG | 905 | In Stock |
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| 25MG | 1321 | In Stock |
|
| 50MG | 1693 | In Stock |
|
| 100MG | 2353 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAZD4747
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NoteResearch use only, not for human use.
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Brief DescriptionAZD4747 is a selective and potent inhibitor of the mutant GTPase KRASG12C that crosses the blood-brain barrier and has potential antitumor activity for the study of pancreatic and colorectal adenocarcinoma.
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DescriptionAZD4747 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorKras
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Research Area——
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Indication——
Chemical Information
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CAS Number2489226-14-2
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Formula Weight440.89
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Molecular FormulaC24H22ClFN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (567.03 mM; Ultrasonic )
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SMILESO=C(C=C)N1CCN2CC3=CC(C#CC)=C(C(F)=C3OCC2C1)C=4C(Cl)=CC=CC4O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kettle JG, et al. Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration. J Med Chem. 2023 Jul 13;66(13):9147-9160.?
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