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LIT-001

CAS No. 2245072-21-1

LIT-001( —— )

Catalog No. M22581 CAS No. 2245072-21-1

LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 166 In Stock
5MG 117 In Stock
10MG 188 In Stock
25MG 353 In Stock
50MG 500 In Stock
100MG 732 In Stock
200MG 995 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    LIT-001
  • Note
    Research use only, not for human use.
  • Brief Description
    LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.
  • Description
    LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD).
  • In Vitro
    In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.
  • In Vivo
    LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD ). Animal Model:Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background) Dosage:10, 20 mg/kg Administration:i.p.Result:Alleviated core symptoms in the context of ASD.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    oxytocin receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2245072-21-1
  • Formula Weight
    645.7
  • Molecular Formula
    C30H34F3N7O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:247 mg/mL (382.53mM; Need ultrasonic)
  • SMILES
    OC(=O)C(F)(F)F.CN(C)C(=S)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61(19):8670-8692.
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