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CHLOROQUINE

CAS No. 54-05-7

CHLOROQUINE( —— )

Catalog No. M22541 CAS No. 54-05-7

Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 40 In Stock
100MG 49 In Stock
200MG 85 In Stock
500MG 170 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    CHLOROQUINE
  • Note
    Research use only, not for human use.
  • Brief Description
    Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
  • Description
    Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased. Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro.Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV-1|autophagy|TLR|SARS-COV-2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    54-05-7
  • Formula Weight
    319.87
  • Molecular Formula
    C18H26ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:100 mg/mL (312.63 mM); Ethanol:100 mg/mL (312.63 mM; Need ultrasonic)
  • SMILES
    CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.
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