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CHLOROQUINE
CAS No. 54-05-7
CHLOROQUINE( —— )
Catalog No. M22541 CAS No. 54-05-7
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 40 | In Stock |
|
| 100MG | 49 | In Stock |
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| 200MG | 85 | In Stock |
|
| 500MG | 170 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCHLOROQUINE
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NoteResearch use only, not for human use.
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Brief DescriptionChloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis.
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DescriptionChloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased. Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro.Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIV-1|autophagy|TLR|SARS-COV-2
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Research Area——
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Indication——
Chemical Information
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CAS Number54-05-7
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Formula Weight319.87
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Molecular FormulaC18H26ClN3
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL (312.63 mM); Ethanol:100 mg/mL (312.63 mM; Need ultrasonic)
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SMILESCCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.
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