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Xanthinol Nicotinate
CAS No. 437-74-1
Xanthinol Nicotinate( Complamin,Angioamin )
Catalog No. M22511 CAS No. 437-74-1
Xanthinol Nicotinate is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased energy.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 31 | In Stock |
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| 50MG | 44 | In Stock |
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| 100MG | 78 | In Stock |
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| 200MG | 126 | In Stock |
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| 500MG | 272 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameXanthinol Nicotinate
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NoteResearch use only, not for human use.
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Brief DescriptionXanthinol Nicotinate is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased energy.
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DescriptionXanthinol Nicotinate is a potent vasodilator that can easily enter the cell and causes an increase in glucose metabolism resulting in an increased energy.(In Vitro):Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 μM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner.Xanthinol Nicotinate (2.76-276 μM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs.(In Vivo):Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration.Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors.
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In VitroXanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 μM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner. Xanthinol Nicotinate (2.76-276 μM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs. Cell Proliferation Assay Cell Line:human umbilical artery smooth muscle cell (HUASMC) Concentration:2.76, 27.6 or 276 μM Incubation Time:for 24 hours Result:Inhibited HUASMC proliferation in a dose-dependent manner. Western Blot Analysis Cell Line:HUASMC Concentration:2.76, 27.6 or 276 μM Incubation Time:for 24 hours Result:Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs.
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In VivoXanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration. Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4). Animal Model:5 week-old male NMRI mice Dosage:75 mg/kg Administration:IP Result:Rapidly and transiently modified tumor pO2 and Maximal pO2 values were obtained 10 to 30 minutes after XN administration.
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SynonymsComplamin,Angioamin
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number437-74-1
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Formula Weight434.45
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Molecular FormulaC13H21N5O4.C6H5NO2
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Purity>98% (HPLC)
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SolubilityH2O:250 mg/mL (575.44 mM; Need ultrasonic)
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SMILESOC(=O)c1cccnc1.CN(CCO)CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Davis E , Rozov H . Xanthinol nicotinate in peripheral vascular disease[J]. Practitioner, 1975, 215(1290):793-798.
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