Cart
sales@molnova.com
Home - Products - Others - Other Targets - TD-165

TD-165

CAS No. 2305936-56-3

TD-165( —— )

Catalog No. M27017 CAS No. 2305936-56-3

TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 338 In Stock
5MG 235 In Stock
10MG 353 In Stock
25MG 708 In Stock
50MG 1004 In Stock
100MG 1376 In Stock
200MG 1851 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TD-165
  • Note
    Research use only, not for human use.
  • Brief Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.
  • Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a CRBN ligand binding group, a linker and a VHL binding group.(In Vitro):Administration of 0.1-10 μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4 nM and a maximum degradation (Dmax) value of 99.6%.
  • In Vitro
    TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4?nM and 99.6%, respectively.TD-165 (0.1-10?μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells.Cell Viability Assay Cell Line:HEK293T cells Concentration:0-100 nM Incubation Time:24 hours Result:Exhibited an DC50 value of 20.4?nM.Western Blot Analysis Cell Line:HEK293T cells Concentration:0.1, 1, and 10?μM Incubation Time:24 hours Result:Decreased the level of CRBN protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2305936-56-3
  • Formula Weight
    870.08
  • Molecular Formula
    C46H59N7O8S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (57.47 mM)
  • SMILES
    Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.XiaoyeGeng, et al. Design and fabrication of reversible thermochromic microencapsulated phase change materials for thermal energy storage and its antibacterial activity. Energy. Volume 159, 15 September 2018, Pages 857-869.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Phenprobamate

    Phenprobamate (MH 532) is a relaxant that acts on central skeletal muscle and has anticonvulsant and psychostimulant effects.

  • Lupanine

    Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-channels of pancreatic beta cells.

  • Sarafotoxin B|SARAFO...

    Sarafotoxin S6b is a vasoconstrictor peptide, and a non-selective endothelin receptor agonist. Sarafotoxin S6b can induce contraction in isolated human coronary arteries , the Ki values of Coronary artery, Saphenous vein and Coronary artery are 0.27, 0.55 and 19.5 nM, respectively.

Sign In Join Free