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(Nle4)-α-MSH
CAS No. 64887-70-3
(Nle4)-α-MSH( ——— )
Catalog No. M40255 CAS No. 64887-70-3
(Nle4)-α-MSH is a synthetic analogue of α-MSH, a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name(Nle4)-α-MSH
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NoteResearch use only, not for human use.
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Brief Description(Nle4)-α-MSH is a synthetic analogue of α-MSH, a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.
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Description(Nle4)-α-MSH is a synthetic analogue of α-MSH, a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.
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In Vitro(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity.(Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells .(Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicatingdarkening response of frog skins.(Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase.
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In Vivo———
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Synonyms———
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PathwayOthers
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TargetOther Targets
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Recptortyrosinase; melanoma adenylate cyclase
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Research Area———
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Indication———
Chemical Information
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CAS Number64887-70-3
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Formula Weight1646.85
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Molecular FormulaC78H111N21O19
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Purity>98% (HPLC)
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Solubility———
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SMILES———
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8. ?
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