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Raphin1 acetate
CAS No. 2242616-04-0
Raphin1 acetate( —— )
Catalog No. M22087 CAS No. 2242616-04-0
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 42 | In Stock |
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| 5MG | 39 | In Stock |
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| 10MG | 62 | In Stock |
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| 25MG | 112 | In Stock |
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| 50MG | 166 | In Stock |
|
| 100MG | 249 | In Stock |
|
| 200MG | 365 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRaphin1 acetate
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NoteResearch use only, not for human use.
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Brief DescriptionRaphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.
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DescriptionRaphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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Recptorphosphatase?PPP1R15B (R15B)
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Research Area——
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Indication——
Chemical Information
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CAS Number2242616-04-0
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Formula Weight291.13
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Molecular FormulaC10H12Cl2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO:40 mg/mL?(137.4 mM;?Need ultrasonic)
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SMILESCC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19.
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