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DORA-22
CAS No. 1088991-95-0
DORA-22( —— )
Catalog No. M22081 CAS No. 1088991-95-0
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 332 | In Stock |
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| 2MG | 188 | In Stock |
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| 5MG | 283 | In Stock |
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| 10MG | 430 | In Stock |
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| 25MG | 710 | In Stock |
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| 50MG | 977 | In Stock |
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| 100MG | 1321 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDORA-22
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NoteResearch use only, not for human use.
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Brief DescriptionDORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.
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DescriptionDORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryDORA-22, a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory.DORA-22 treatment improved the insomnia-related sleep disruption-wake was attenuated and NREM sleep was normalized. REM sleep amounts were enhanced compared with vehicle treatment for one dose (30 mg/kg). In the first hour of insomnia model exposure, DORA-22 promoted the number and average duration of NREM sleep spindles, which have been previously proposed to play a role in memory consolidation (all doses). Water maze measures revealed probe trial performance improvement for select doses of DORA-22, including increased time spent in the platform quadrant (10 and 30 mg/kg) and time spent in platform location and number of platform crossings (10 mg/kg only). In conclusion, DORA-22 treatment improved insomnia-related sleep disruption and memory consolidation deficits.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOX Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1088991-95-0
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Formula Weight424.4
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Molecular FormulaC23H22F2N4O2?
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(F)ccc1-c1ncccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gamble M C , Katsuki F , Mccoy J G , et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model[J]. Sleep, 2019.
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