Cart
sales@molnova.com
PNU-282987
CAS No. 123464-89-1
PNU-282987 ( ——— )
Catalog No. M38006 CAS No. 123464-89-1
PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 60 | Get Quote |
|
| 10MG | 99 | Get Quote |
|
| 25MG | Get Quote | Get Quote |
|
| 50MG | Get Quote | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
Biological Information
-
Product NamePNU-282987
-
NoteResearch use only, not for human use.
-
Brief DescriptionPNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
-
DescriptionPNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM.
-
In VitroPNU-282987 (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM.PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM.PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM.
-
In VivoPNU-282987 (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit.PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner.Animal Model:Rats Dosage:1, 3 mg/kg Administration:i.v.Result:Significantly reversed amphetamine-induced gating deficit.
-
Synonyms———
-
PathwayOthers
-
TargetOther Targets
-
Recptor5-HT Receptor
-
Research Area———
-
Indication———
Chemical Information
-
CAS Number123464-89-1
-
Formula Weight301.21
-
Molecular FormulaC14H18Cl2N2O
-
Purity>98% (HPLC)
-
Solubility?H2O : 50 mg/mL (166.00 mM; ultraphonic) DMSO : 10 mg/mL (33.20 mM; ultraphonic (<60°C)
-
SMILESCl.C1CN2CCC1[C@H](C2)NC(=O)c1ccc(cc1)Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Alice L Bodnar, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem?
molnova catalog
related products
-
BOC-Dap-NE
Boc-Dap-NE used in the synthesis of antibody-drug conjugates (ADCs).It is a cleavable ADC linker.
-
Laetrile
Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
-
Neuromedin S (rat)
Potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Induces phase shifts in the circadian rhythm of locomotor activity following i.c.v. administration. Potent endogenous anorexigenic peptide.
