TNO155( —— )

Catalog No. M22015 CAS No. 1801765-04-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TNO155
Note

Research use only, not for human use.
Brief Description

TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.
Description

TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity.
In Vitro

Cell Proliferation Assay Cell Line:PC-9, PC-9 EGFRT790M/C797S, HCC827, HCC827-GR (gefinitib-resistant)Concentration:0-1000 nM Incubation Time:6 days Result:Inhibited cell viability with IC50s of 1.56, 1.38, 0.77 and 1.38 μM against PC-9 and PC-9 EGFRT790M/C797S, HCC827 and HCC827-GR cells, respectively. Western Blot Analysis Cell Line:PC-14 (EGFRex19del)Concentration:3 μM Incubation Time:4h and 24 h Result:Effectively reduced p-ERK levels at 4 hours but suffered a rebound at 24 hours.
In Vivo

Animal Model:Female athymic nude mice bearing HT-29 xenografts Dosage:20 mg/kg alone or 10 mg/kg in combination with Dabrafenib and Trametinib Administration:PO, twice daily for 40 days Result:Resulted in moderate tumor growth inhibition. Maintained tumor stasis for more than 40 days when combined with Dabrafenib plus Trametinib.
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Phosphatase
Recptor

SHP-2
Research Area

Cancer
Indication

Advanced Cancer,Metastatic Cancer,Malignant Neoplastic Disease

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