Cart
sales@molnova.com
RMC-4550
CAS No. 2172651-73-7
RMC-4550( —— )
Catalog No. M26806 CAS No. 2172651-73-7
RMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
|
| 5MG | 116 | In Stock |
|
| 10MG | 188 | In Stock |
|
| 25MG | 432 | In Stock |
|
| 50MG | 625 | In Stock |
|
| 100MG | 889 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRMC-4550
-
NoteResearch use only, not for human use.
-
Brief DescriptionRMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).
-
DescriptionRMC-4550 is an effective and allosteric inhibitor of SHP2 (IC50: 0.583 nM).(In Vitro):RMC-4550 stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide but lacks activity against the free catalytic domain of SHP2 .(In Vivo):RMC-4550 has moderate to high bioavailability and has a half-life amenable for once daily oral administration. In the EGFR-driven KYSE-520 human esophageal cancer xenograft model, RMC-4550 has a dose dependent efficacy consistent with target modulation, assessed by phospho-ERK inhibition in tumors. RMC-4550 is well tolerated at doses that achieved maximal and sustained efficacy in this model.
-
In VitroRMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2.
-
In Vivo——
-
Synonyms——
-
PathwayMetabolic Enzyme/Protease
-
TargetPhosphatase
-
RecptorS. aureus
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2172651-73-7
-
Formula Weight437.37
-
Molecular FormulaC21H26Cl2N4O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (228.64 mM)
-
SMILESC[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Jian-Ming, Shi-Chang, Sun, et al. Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antibiotic resistance of drug-resistant Staphylococcus aureus.[J]. International journal of antimicrobial agents, 2018.
molnova catalog
related products
-
NSC-87877
NSC-87877 is an effective inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (IC50=0.318 μM, 0.355 μM of shp2 and shp1, respectively).It also inhibits dual-specificity phosphatase 26 (DUSP26).
-
h-NTPDase8-IN-1
h-NTPDase8-IN-1 is a specific aminosulfonylbenzamide inhibitor of h-NTPDases8 (IC 50 = 0.28 ± 0.07 μM). h-NTPDase8-IN-1 can be used to study diseases brought about by aberrant h -NTPDase expression.
-
JMS-053
JMS-053 is a potent and selective inhibitor of the phosphatase DUSP3, inhibits PTP4A3, PTP4A1, PTP4A2 and CDC25B, inhibits cancer cell migration and sphere growth, and avoids disruption of the microvascular endothelial barrier by vascular endothelial growth factor or lipopolysaccharide.
