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PU-02
CAS No. 313984-77-9
PU-02( 6-[(1-Naphthalenylmethyl)thio]-9H-purine )
Catalog No. M21984 CAS No. 313984-77-9
PU-02 is a potent and selective antagonist of 5-HT3 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 31 | In Stock |
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| 10MG | 55 | In Stock |
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| 25MG | 107 | In Stock |
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| 50MG | 193 | In Stock |
|
| 100MG | 310 | In Stock |
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| 200MG | 445 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePU-02
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NoteResearch use only, not for human use.
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Brief DescriptionPU-02 is a potent and selective antagonist of 5-HT3 receptor.
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DescriptionPU-02 is a potent and selective antagonist of 5-HT3 receptor.
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In VitroPU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity. Apoptosis AnalysisCell Line:HepG2 cells.Concentration:6.26, 12.5, 25, 50 μM.Incubation Time:6, 12, 24, 36 h.Result:Induced mitochondria-dependent apoptosis.
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In Vivo——
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Synonyms6-[(1-Naphthalenylmethyl)thio]-9H-purine
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT3
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Research Area——
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Indication——
Chemical Information
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CAS Number313984-77-9
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Formula Weight292.36
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Molecular FormulaC16H12N4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (855.11 mM)
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SMILESC(Sc1ncnc2nc[nH]c12)c1cccc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Trattnig S M , Harpsoe K , Thygesen S B , et al. Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE[J]. Journal of Biological Chemistry, 2012, 287(30):25241-25254.
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