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PU-02

CAS No. 313984-77-9

PU-02( 6-[(1-Naphthalenylmethyl)thio]-9H-purine )

Catalog No. M21984 CAS No. 313984-77-9

PU-02 is a potent and selective antagonist of 5-HT3 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 35 In Stock
5MG 31 In Stock
10MG 55 In Stock
25MG 107 In Stock
50MG 193 In Stock
100MG 310 In Stock
200MG 445 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PU-02
  • Note
    Research use only, not for human use.
  • Brief Description
    PU-02 is a potent and selective antagonist of 5-HT3 receptor.
  • Description
    PU-02 is a potent and selective antagonist of 5-HT3 receptor.
  • In Vitro
    PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity. Apoptosis AnalysisCell Line:HepG2 cells.Concentration:6.26, 12.5, 25, 50 μM.Incubation Time:6, 12, 24, 36 h.Result:Induced mitochondria-dependent apoptosis.
  • In Vivo
    ——
  • Synonyms
    6-[(1-Naphthalenylmethyl)thio]-9H-purine
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    313984-77-9
  • Formula Weight
    292.36
  • Molecular Formula
    C16H12N4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (855.11 mM)
  • SMILES
    C(Sc1ncnc2nc[nH]c12)c1cccc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Trattnig S M , Harpsoe K , Thygesen S B , et al. Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE[J]. Journal of Biological Chemistry, 2012, 287(30):25241-25254.
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