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Home - Products - GPCR/G Protein - Histamine Receptor - JNJ 39220675

JNJ 39220675

CAS No. 959740-39-7

JNJ 39220675( JNJ39220675 | JNJ-39220675 )

Catalog No. M16848 CAS No. 959740-39-7

JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    JNJ 39220675
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
  • Description
    JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3; dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats, reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.Other Indication Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    JNJ39220675 | JNJ-39220675
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    959740-39-7
  • Formula Weight
    369.44
  • Molecular Formula
    C21H24FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1CCCN(C2CCC2)CC1)c3cnc(Oc4ccc(F)cc4)cc3
  • Chemical Name
    (4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4. 2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41. 3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63. 4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
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