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JNJ 39220675
CAS No. 959740-39-7
JNJ 39220675( JNJ39220675 | JNJ-39220675 )
Catalog No. M16848 CAS No. 959740-39-7
JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 411 | In Stock |
|
| 10MG | 562 | In Stock |
|
| 25MG | 866 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameJNJ 39220675
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NoteResearch use only, not for human use.
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Brief DescriptionJNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3.
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DescriptionJNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3; dose-dependently reduces both alcohol intake and preference in alcohol-preferring rats, reduces alcohol self-administration without changing saccharin self-administration in alcohol non-dependent rats.Other Indication Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsJNJ39220675 | JNJ-39220675
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PathwayGPCR/G Protein
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TargetHistamine Receptor
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RecptorHistamine Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number959740-39-7
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Formula Weight369.44
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Molecular FormulaC21H24FN3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1CCCN(C2CCC2)CC1)c3cnc(Oc4ccc(F)cc4)cc3
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Chemical Name(4-cyclobutyl-1,4-diazepan-1-yl)(6-(4-fluorophenoxy)pyridin-3-yl)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Letavic MA, et al. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4210-4.
2. Galici R, et al. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
3. Nuutinen S, et al. Neuropharmacology. 2016 Jul;106:156-63.
4. Vanhanen J, et al. Br J Pharmacol. 2013 Sep;170(1):177-87.
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