Notopterol( Notopterol )

Catalog No. M19223 CAS No. 88206-46-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Notopterol
Note

Research use only, not for human use.
Brief Description

Notopterol induces apoptosis and inhibits cell cycle-specific.
Description

Notopterol is an analgesic compound with anti-inflammatory action isolated from Notopterygium incisum Ting.
In Vitro

notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner. notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner. Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells. Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP.
In Vivo

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Synonyms

Notopterol
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Others
Research Area

Others-Field
Indication

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CAS Number

88206-46-6
Formula Weight

354.4
Molecular Formula

C21H22O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (282.17 mM)
SMILES

CC(=CC(CC(=CCOC1=C2C=CC(=O)OC2=CC3=C1C=CO3)C)O)C
Chemical Name

7H-Furo(3,2-g)(1)benzopyran-7-one, 4-((5-hydroxy-3,7-dimethyl-2,6-octadienyl)oxy)-, (E)-