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ML349
CAS No. 890819-86-0
ML349( —— )
Catalog No. M21729 CAS No. 890819-86-0
ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
|
| 5MG | 68 | In Stock |
|
| 10MG | 115 | In Stock |
|
| 25MG | 250 | In Stock |
|
| 50MG | 410 | In Stock |
|
| 100MG | 605 | In Stock |
|
| 500MG | 1287 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameML349
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NoteResearch use only, not for human use.
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Brief DescriptionML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM.
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DescriptionML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.(In Vitro):ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
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In VitroML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kisof>10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number890819-86-0
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Formula Weight454.56
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Molecular FormulaC??H??N?O?S?
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Purity>98% (HPLC)
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SolubilityDMSO : 20 mg/mL (44.00 mM; Need ultrasonic)
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SMILESCOC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Won SJ, et al. Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2). ACS Chem Biol. 2016 Dec 16;11(12):3374-3382.
2. Adibekian A, et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).
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